Nuclear Factor, Erythroid Derived 2 Like Protein 3 (NFE2L3)

NFE2-binding sites and Maf recognition elements (MAREs) are essential cis-acting elements in the regulatory regions of erythroid-specific genes recognized by the erythroid transcription factor NFE2, which is composed of p45 and a small MAF protein. The p45 subunit and the p45-related factors NRF1 (NFE2L1) and NRF2 (NFE2L2) contain a Cap'n'collar (CNC)-type basic leucine zipper (bZIP) domain, and they are collectively grouped as the CNC family. The cDNA sequence encodes a novel 694-amino acid polypeptide, which the authors called NRF3. NRF3 contains a bZIP domain that is similar to those of other CNC transcription factors. Northern blot analysis detected 2 human NRF3 transcripts in all tissues examined, with the highest levels in placenta. NRF3 was expressed in B- and monocytic cell lines but not in T-cell lines.