Nuclear Factor I/C (NFIC)

Grunder et al. (2003) determined that the NFIC gene contains 11 exons. By ortholog comparisons using protein sequences from 7 vertebrate species, they identified 11 NFIC variants that are produced by alternative splicing.

Qian et al. (1995) localized the NFIC and NFIX genes to chromosome 19p13.3 by fluorescence in situ hybridization. By FISH, Grunder et al. (2003) mapped the mouse Nfic gene to the distal region of chromosome 10C.

Molar crown development was normal, but molars lacked roots, mandibular incisors were thin and brittle, and maxillary incisors were weakened and appeared abnormal. Feeding in Nfic-null mice was severely impaired; however, mutants well nourished by a soft-dough diet were fertile and had normal life spans.