Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin Dependent 2 Interacting Protein (NFATC2IP)

Post-translational modification by Small Ubiquitin-like Modifiers (SUMO) has been implicated in protein targeting, in the maintenance of genomic integrity and in transcriptional control. But the specific molecular effects of SUMO modification on many target proteins remain to be elucidated. Members from animals, fungi and plants, most prominent being yeast Rad60, Esc2 and mouse NIP45. Different proteins of the novel family are known to interact directly with histone NAD-dependent deacetylases (HDACs), structural maintenance of chromosomes (SMC) proteins, and transcription factors. In particular, the highly non-trivial designation of the first of the two successive SUMO-domains in non-plant RENi provides a rationale for previously published functionally impaired mutant variants.