Nuclear Localized Factor 3 (NLF3)

As part of a large-scale cDNA cloning project, Nagase et al. (2001) cloned KIAA1957 from a human fetal brain cDNA library. NLF3 encodes a predicted protein of 481 amino acids.

By analysis of human protein sequence databases with the sequence of NLF1 and NLF2 as query, Warton et al. (2004) determined that KIAA1957 shows approximately 30% homology with NLF1 and NLF2. KIAA1957, NLF1, and NLF2 contain 2 homologous domains, one of which is 100% identical among the 3 proteins and contains a predicted nuclear localization sequence. KIAA1957 and its mouse ortholog share 88% amino acid homology.