Nuclear Receptor Binding Factor 2 (NRBF2)

COPR1; COPR2; NRBF-2; Comodulator of PPAR and RXR

Nuclear Receptor Binding Factor 2 (NRBF2)
A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.
NRBF2 was originally identified in a yeast two-hybrid screen for factors that interact with the peroxisome proliferator-activated receptor alpha. NRBF2 was also identified in a screen of a keratinocyte cDNA library and named COPR. NRBF2 was proposed to function as a modulator of transcriptional activity that functions to decrease rather than completely repress nuclear-receptor mediated gene expression. Alternative names for NRBF2 include COPR1, COPR2, and NRBF-2.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)