Nuclear Receptor Coactivator 4 (NCOA4)

NCOA4 interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.The interaction between the AR bait and NCOA4 occurred only in the presence of dihydrotestosterone. The deduced 614-amino acid protein has a calculated molecular mass of 70 kD.mouse tissues detected highest expression of Ara70 in thymus, prostate, testis, and adrenal gland. Intermediate expression was found in several other mouse tissues, and no expression was detected in brain cortex, liver, spleen, and seminal vesicle.