Nuclear Receptor Interacting Protein 3 (NRIP3)

NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements. Using microarray and RT-PCR analyses, Zhong et al. (2007) found that the NRIP3 gene was downregulated in all 9 nonsmall cell lung cancer (NSCLC) cell lines examined compared with normal controls.

Semiquantitative RT-PCR showed downregulation of NRIP3 in 4 of 8 lung tumor samples compared with adjacent normal tissue. The promoter region of NRIP3 was highly methylated in 1 NSCLC cell line and partially methylated in 4 others, and treatment of several NSCLC cell lines with a combination of DNA methylation and histone deacetylase inhibitors restored NRIP3 expression.the promoter region of the NRIP3 gene contains a CpG island.