Nuclear Receptor Subfamily 2, Group F, Member 1 (NR2F1)

NR2F1 is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.COUP-TFs are expressed in many tissues and in various cell lines. Furthermore, in situ hybridization experiments demonstrated that COUP-TFs are highly expressed during mouse embryonic development. Their expression patterns are spatially and temporally regulated, suggesting that COUP-TFs may be involved in organogenesis. Two COUP-TF genes have been cloned in the human: COUP-TFI, also referred to as EAR3 and NR2F1, and COUP-TFII, also called ARP1.