Nucleoporin 43kDa (NUP43)

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160.

NUP43 contains WD repeats and has a calculated molecular mass of about 42 kD. Fluorescence-tagged NUP43, transfected into HeLa cells, showed punctate nuclear rim localization typical of nucleoporins.NUP43 and several other WD-repeat nucleoporins are constituents of the Nup107-160 complex. All constituents of this complex were targeted to kinetochores from prophase to anaphase during mitosis.