Nucleoside Diphosphate Linked Moiety X-Type Motif 13 (NUDT13)

Nudix Type Motif 13; Protein KiSS-16

Nucleoside Diphosphate Linked Moiety X-Type Motif 13 (NUDT13)
By database analysis, Abdelraheim et al. (2003) identified NUDT13, which encodes a mitochondrial NADH diphosphatase. By genomic sequence analysis, Abdelraheim et al. (2003) mapped the NUDT13 gene to chromosome 10q22.3.
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT13, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances.Highest activity was observed against NADPH, NADH, and diadenosine diphosphate. Moderate activity was observed with FAD, NADP+, NAD+, ADP-ribose, and diadenosine triphosphate. It showed an absolute dependence on bivalent cations, with maximum activity in the presence of Mn(2+).

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)