Nucleosome Assembly Protein 1 Like Protein 2 (NAP1L2)

Bpx, which is specifically expressed in the brain, shows strong homology to genes encoding nucleosome assembly proteins and is normally X-inactivated in mice. Isolation and localization of BPX, its human homolog, showed that the gene is located centromeric to XIST in man. The authors concluded that the Xq13 region, in which gene orientation is apparently globally conserved between man and mouse, must therefore contain an inversion of at least 600 kb spanning the XIST sequence and including the CDX4 and BPX genes. (BPX is presumably for 'brain protein on X.') See also NAP1L1.Protein expression studies showed that the Nap1l2 protein binds to condensing chromatin during S phase and in apoptotic cells, but remains cytoplasmic during G1 phase.