Numb Like Protein (NUMBL)

The Drosophila 'numb' gene encodes a membrane-associated protein that is predominantly segregated to only 1 of the daughter cells of dividing neural precursors after division, allowing the 2 daughter cells to adopt distinct fates. Studies with mouse Numb in dividing ventricular cells during cortical neurogenesis suggested that Numb suppresses Notch1 activity in the daughter cell, allowing it to remain as a progenitor while the other daughter cell migrates to the cortical plate and terminally differentiates into a neuron.In mouse, the Nbl gene was preferentially expressed in adult and embryonic nervous system. In the developing neocortex, Nbl was expressed in postmitotic neurons in the cortical plate, but not in progenitor cells within the ventricular zone.