OTU Domain Containing Protein 5 (OTUD5)

OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. In addition to an OTU domain, DUBA contains a ubiquitin action motif (UIM) at its carboxy terminus. The 2,759-basepair mRNA contains an open reading frame (ORF) predicting a 571-amino acid protein.