Obscurin Like Protein 1 (OBSL1)

The variants could be arranged in 3 main groups, A, B, or C, depending upon which of 3 alternative translation stop codons was used. The encoded proteins ranged in predicted molecular mass from 130 to 230 kD.

Immunohistochemical analysis of isolated rat cardiac myocytes localized Obsl1 to the intercalated disc, to the perinuclear region, and overlying the Z lines and, to a lesser extent, the M bands. Accumulation of Obsl1 was noted between adjacent but not yet fused myofibrils. In these areas, Obsl1 was arranged in a linear or dotted pattern with accumulation overlying the Z lines. In cultured rat cardiac myocytes, the localization of Obsl1 was dynamic. The intracellular protein distribution of OBSL1 and its domain organization led Geisler et al. (2007) to propose that OBSL1 is a cytoskeletal adaptor.