Octamer Binding Transcription Factor 11 (OCT11)

Goldsborough et al. (1993) cloned mouse Oct11 from a thymus cDNA library. PCR analysis revealed Oct11 expression only in testis, thymus, and 14.5 days postcoitum embryos. PCR and Northern blot analysis also revealed expression in some myeloma cell lines. Using mouse Skn1a as probe, followed by 3-prime RACE, Hildesheim et al. (1999) cloned full-length POU2F3, which they called SKN1A, from a primary keratinocyte cDNA library.

The deduced 436-amino acid protein contains an N-terminal POU-specific domain, a hypervariable linker region, and a C-terminal POU homeodomain. The human and rat proteins share approximately 90% sequence identity, and sequences within the POU domain only diverge within the hypervariable linker region.