Octamer Binding Transcription Factor 7 (OCT7)

POU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1) and Oct2 (POU2F2) and the pituitary protein Pit1 (PIT1). Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.The protein is expressed in the CNS during development and in adult brain. Expressed specifically in the neuroectodermal cell lineage.