Octamer Binding Transcription Factor 9 (OCT9)

De Kok et al. (1995) used PCR primers complementary to the murine gene sequences to amplify a human POU3F4 fragment from cosmid DNA, which was then used as a probe to screen a human fetal brain cDNA library. They isolated 1.4 kb of the human POU3F4 cDNA sequence, which contained the complete 1,083-bp protein coding region. The rat and mouse proteins are completely identical, and the human protein contains only 4 conservative amino acid substitutions.

Douville et al. (1994) showed that the rat homolog of POU3F4, called RHS2, is expressed during embryonic development in the brain, the neural tube, and the otic vesicle at 15.5 and 17.5 days after conception.