Odd Skipped Related Protein 2 (OSR2)

OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors.Osr2 expression in a dynamic pattern during craniofacial, limb, and kidney development with expression first detected at embryonic day (E) 9.5 in the mesonephric vesicles, followed by expression in the mesenchyme adjacent to the maxillary processes. In developing limb buds, Osr2 expression follows a distinct dorsal to ventral developmental time sequence. Mouse Osr2 was expressed at sites of epithelial-mesenchyme interaction during tooth and kidney development. Osr2 shares 65% amino acid identity with Osr1 and 98% identity over the zinc finger domains.In the luciferase assay, the opposite results were obtained with Osr2a activating and Osr2b repressing transcription.