Oligomycin Sensitivity Conferring Protein (OSCP)

One of these nuclear genes (ATP5O) encodes the oligomycin sensitivity-conferring protein (OSCP) of ATP synthase and has been described from yeast, cow, and mouse. OSCP is a component of the 'stalk' region connecting the F1 and F0 domains of the ATP synthase complex.

The authors used exon trapping from pools of chromosome 21-specific cosmids to identify a portion of the gene, which was then used to screen a fetal brain cDNA library. The predicted polypeptide is 213 amino acids long with more than 80% identity to the bovine and mouse homologs. Northern blots showed that the gene was expressed in all human tissues examined and at highest levels in muscle and heart.