Ornithine Aminotransferase Like Protein 1 (OATL1)

Based on sequence analysis, Bernards (2003) determined that the TBC1D25 gene, earlier designated OATL1, is a member of a large superfamily of Ras GTPase activating proteins. TBC1D25 encodes a 688-amino acid protein with a TBC domain. Bernards (2003) noted that TBC domain proteins contain a 200- to 240-amino acid Ypt/RabGAP catalytic domain found in the human TRE2 oncogene and the yeast Bub2p and Cdc16 spindle checkpoint proteins.Barrett et al. (1987) identified 2 gene sequences at Xp11.2 that were similar to the ornithine aminotransferase (OAT) sequence. Lafreniere et al. (1991) refined the localization of the X-linked sequences homologous to OAT: OATL1 mapped to Xp11.3-p11.23 (distal), while OATL2 mapped to Xp11.22-p11.21 (proximal)