Osteosarcoma Amplified 9 (OS9)
ERLEC2; Amplified In Osteosarcoma; Endoplasmic Reticulum Lectin 2; Erlectin 2
Protein OS-9 is a protein that is highly expressed in osteosarcomas.This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The deduced 667-amino acid protein has a calculated molecular mass of 75.6 kD. OS9 contains an N-terminal leader peptide, a 211-amino acid hydrophilic region with 8 cysteines, and an acidic region with multiple predicted hydrophilic helices. It also has a putative nuclear targeting signal. The hydrophilic region of OS9 is highly conserved in human, S. cerevisiae, and C. elegans, with complete conservation of the 8 cysteines.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC693Hu01 Recombinant Osteosarcoma Amplified 9 (OS9) In Stock
- Polyclonal antibody PAC693Hu01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) In Stock
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Organism species: Mus musculus (Mouse)
- Recombinant protein RPC693Mu01 Recombinant Osteosarcoma Amplified 9 (OS9) In Stock
- Polyclonal antibody PAC693Mu01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) In Stock
- Customized Service n/a CLIA Kit for Osteosarcoma Amplified 9 (OS9) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Osteosarcoma Amplified 9 (OS9) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPC693Ra01 Recombinant Osteosarcoma Amplified 9 (OS9) In Stock
- Polyclonal antibody PAC693Ra01 Polyclonal Antibody to Osteosarcoma Amplified 9 (OS9) In Stock
- Customized Service n/a CLIA Kit for Osteosarcoma Amplified 9 (OS9) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Osteosarcoma Amplified 9 (OS9) ELISA Kit Customized Service Offer