Oxysterol Binding Protein Like Protein 3 (OSBPL3)

OSBPL3 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.

Sequence analysis predicted that the 887-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 amino acids that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in its N terminus. ORP3 is 73% and 62% identical to OSBPL6 and OSBPL7, respectively, in the PH domain. The 3 proteins are approximately 76% identical in the SB domain.