Oxysterol Binding Protein Like Protein 6 (OSBPL6)

OSBPL6 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.

Sequence analysis predicted that the 934-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in the N terminus. OSBPL6 is approximately 74% identical to OSBPL3 and OSBPL7 in the SB domain and 73% and 69% identical, respectively, in the PH domain.