PDZ Domain Containing RING Finger Protein 3 (PDZRN3)

By sequencing clones obtained from an adult brain cDNA library, Kikuno et al. (1999) cloned PDZRN3, which they designated KIAA1095. The deduced 1,098-amino acid protein contains a C3HC4 zinc finger motif. RT-PCR ELISA detected high expression in heart, whole brain, lung, skeletal muscle, ovary, spinal cord, thalamus, amygdala, and fetal whole brain. Lower expression was detected in kidney, testis, pancreas, adult and fetal liver, and all other specific brain regions tested. Lowest expression was detected in spleen.

The deduced 1,066-amino acid protein contains an N-terminal RING domain, followed by 2 PDZ domains and 2 C-terminal bipartite nuclear localization signals. PDZRN3 shares 59.9% amino acid identity with PDZRN4.