PHD Finger Protein 11 (PHF11)

Using autologous antibody, Scanlan et al. (1999) cloned PHF11, which they designated NY-REN-34, from a clear-cell renal carcinoma cDNA library. The deduced 191-amino acid protein contains a zinc finger motif. RT-PCR detected expression in all normal tissues tested, including lung, testis, small intestine, breast, liver, and placenta.Zhang et al. (2003) cloned PHF11 from a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E (IgE) levels and asthma.PCR analysis detected several splice variants, 1 of which was expressed in all tissues examined. A variant utilizing an alternative exon 1 was expressed in immune-related tissues and cells. Variants utilizing 2 alternative exons following exon 5, both of which contain premature stop codons, were detected only in lung and unactivated peripheral blood leukocytes, but not in activated cells.