PHD Finger Protein 17 (PHF17)

The deduced 702-amino acid protein shares significant similarity with the human zinc finger protein BR140 (BRPF1). RT-PCR ELISA detected very high expression in whole adult brain and intermediate expression in all other tissues examined, including all specific brain regions tested.JADE1 could activate transcription and that deletion of the PHD zinc fingers abolished transcriptional activity. JADE1 also promoted histone H4, but not histone H3 acetylation in a dose-dependent manner, and acetylation required the PHDs. A JADE1 mutant lacking the second PHD behaved in a dominant-negative manner. TIP60 (HTATIP), a histone acetyltransferase with histone H4/H2A specificity, physically associated with JADE1 and augmented JADE1 acetyltransferase function.