PIH1 Domain Containing Protein 1 (PIH1D1)

By database analysis, Gonzales et al. (2005) identified the human homolog of yeast Nop17, PIH1D1.Gonzales et al. (2005) found that deletion of Nop17 caused a temperature-sensitive phenotype in yeast that could be partially rescued by human NOP17. Analysis of Nop17-null yeast suggested that Nop17 is involved in pre-rRNA processing and is required for box C/D small nucleolar ribonucleoprotein assembly or nuclear localization.The International Radiation Hybrid Mapping Consortium mapped the PIH1D1 gene to chromosome 19.

HEK293T cells were effectively treated with CHX and MG132. The degradation of SNF5 was mediated by the proteasome pathway. PIH1D1 regulated the protein level of SNF5 by attenuating its proteasome degradation.