POC1 Centriolar Protein Homolog A (POC1A)

That cells depleted for both POC1A and POC1B show the absence of centrin-staining procentrioles, together with the localization of POC1 protein to procentrioles that have demonstrated, suggests that POC1 may be involved in an early stage of centriole assembly.

POC1 is recruited to nascent procentrioles and localizes in a highly asymmetrical pattern in mature centrioles corresponding to sites of basal-body fiber attachment. Knockdown of POC1 in human cells caused a reduction in centriole duplication, whereas overexpression caused the appearance of elongated centriole-like structures. Together, these data suggest that POC1 is involved in early steps of centriole duplication as well as in the later steps of centriole length control.