POU Domain Class 2 Associating Factor 1 (POU2AF1)

OCAB is essential for V(D)J recombination of a subset of Ig-kappa genes. OCAB modulates recombination by directly enhancing Ig-kappa gene transcription in vivo.the POU dimer from the OCT1 gene formed on the palindromic OCT factor recognition element, or PORE, could recruit the transcriptional coactivator OBF1, whereas POU dimers formed on the consensus MORE or on MOREs from Ig heavy chain promoters failed to interact. An interaction with OBF1 was precluded since the same OCT1 residues that form the MORE dimerization interface are also used for OBF1/OCT1 interactions on the PORE. These findings provided a paradigm of how specific POU dimer assemblies can differentially recruit a coregulatory activity with distinct transcriptional readouts.