POU Domain Class 4 Transcription Factor 3 (POU4F3)

POU4F3 encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.

The BRN3C gene encodes a 338-amino acid polypeptide that contains several identifiable motifs, including a POU domain. Although its splicing pattern is identical to that of BRN3A and BRN3B, the 3 members of the BRN3 family are unlinked.