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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
POU Domain Class 6 Transcription Factor 1 (POU6F1)
BRN5; MPOU; TCFB1
Expression of POU6F1 at messenger RNA and protein was confirmed in cell lines derived from epithelial ovarian carcinoma. The microarray analyses performed using the 2 ovarian cancer microarray data sets available on the Internet indicated that POU6F1 expression was significantly greater in clear cell adenocarcinoma. Immunostaining confirmed the nuclear localization of POU6F1 in clear cell adenocarcinoma (100%).
Exposure to the siRNA for POU6F1 reduced the expression of lysophosphatidic acid receptors, which are G protein-coupled receptors involved in tumor cell proliferation. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines, and a similar effect was confirmed for tumors transplanted into nude mice.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPQ309Hu01 Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Antibodies PAQ309Hu01 Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
MAQ309Hu21 Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Assay Kits SEQ309Hu ELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
SCQ309Hu CLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPQ309Mu01 Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Antibodies PAQ309Mu01 Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
MAQ309Mu21 Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Assay Kits SEQ309Mu ELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
SCQ309Mu CLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPQ309Ra01 Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Antibodies PAQ309Ra01 Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
MAQ309Ra21 Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
Assay Kits SEQ309Ra ELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize
SCQ309Ra CLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) Customize