POU Domain Class 6 Transcription Factor 1 (POU6F1)

BRN5; MPOU; TCFB1; Brain-5; Brain-specific homeobox/POU domain protein 5; mPOU homeobox protein
POU Domain Class 6 Transcription Factor 1 (POU6F1)
Expression of POU6F1 at messenger RNA and protein was confirmed in cell lines derived from epithelial ovarian carcinoma. The microarray analyses performed using the 2 ovarian cancer microarray data sets available on the Internet indicated that POU6F1 expression was significantly greater in clear cell adenocarcinoma. Immunostaining confirmed the nuclear localization of POU6F1 in clear cell adenocarcinoma (100%).
Exposure to the siRNA for POU6F1 reduced the expression of lysophosphatidic acid receptors, which are G protein-coupled receptors involved in tumor cell proliferation. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines, and a similar effect was confirmed for tumors transplanted into nude mice.
Organism species: Homo sapiens (Human)
  • Protein RPQ309Hu01Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyPAQ309Hu01Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyMAQ309Hu21Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSEQ309HuELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSCQ309HuCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPQ309Mu01Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyPAQ309Mu01Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyMAQ309Mu21Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSEQ309MuELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSCQ309MuCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPQ309Ra01Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyPAQ309Ra01Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • AntibodyMAQ309Ra21Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSEQ309RaELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
  • Assay KitSCQ309RaCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)Customize
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