POU Domain Class 6 Transcription Factor 1 (POU6F1)
BRN5; MPOU; TCFB1; Brain-5; Brain-specific homeobox/POU domain protein 5; mPOU homeobox protein
Expression of POU6F1 at messenger RNA and protein was confirmed in cell lines derived from epithelial ovarian carcinoma. The microarray analyses performed using the 2 ovarian cancer microarray data sets available on the Internet indicated that POU6F1 expression was significantly greater in clear cell adenocarcinoma. Immunostaining confirmed the nuclear localization of POU6F1 in clear cell adenocarcinoma (100%).
Exposure to the siRNA for POU6F1 reduced the expression of lysophosphatidic acid receptors, which are G protein-coupled receptors involved in tumor cell proliferation. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines, and a similar effect was confirmed for tumors transplanted into nude mice.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant POU Domain Class 6 Transcription Factor 1 (POU6F1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1) ELISA Kit Customized Service Offer