PR Domain Containing Protein 14 (PRDM14)

The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM14, are often involved in transcriptional regulation. PRDM14 gene encodes a deduced 571-amino acid protein that is 68% identical to the mouse ortholog.

Introduction of PRDM14 into cancer cells with normally low endogenous PRDM14 enhanced cell growth and reduced their sensitivity to various chemotherapeutic drugs. In contrast, siRNA knockdown of PRMD14 induced apoptosis in breast cancer cells and increased their chemotherapeutic drug sensitivity. Little, if any, expression of PRMD14 was detected in normal tissues. PRMD14 may be an ideal therapeutic target for the treatment of breast cancer.