PR Domain Containing Protein 11 (PRDM11)

The PR domain proteins (PRDMs) constitute a sub-family of the SET domain family of histone methyl transferases and consist of 17 family members. Several of the PRDMs have been characterized as tumorsuppressors, including PRDM2, PRDM3, PRDM5 and PRDM16, but the mechanisms are largely unknown.

PRDM11 is a novel putative tumor suppressor in mice and men, whose downregulation may be associated with poor prognosis in DLBCL. H3K27 trimethylation of the PRDM11 promoter may be a novel target for therapy in DLBCL. The gene contains 11 distinct gt-ag introns. Transcription produces 3 alternatively spliced mRNAs. There are 3 probable alternative promotors, 2 non overlapping alternative last exons and 3 validated alternative polyadenylation sites.