PR Domain Containing Protein 5 (PRDM5)

PFM2; PR domain zinc finger protein 5
PR Domain Containing Protein 5 (PRDM5)
PRDM5 is a recently identified family member that functions as a transcriptional repressor and behaves as a putative tumor suppressor in different types of cancer.  Overexpression of PRDM5 mRNA had opposite effects on the development of anterior neural structures, and resulted in embryos with a shorter body axis due to posterior truncation, a bigger head and abnormal somites. In situ hybridization experiments aimed at analyzing the integrity of wnt pathways during gastrulation at the level of the prechordal plate revealed inhibition of non canonical PCP wnt signaling in embryos overexpressing PRDM5, and over-activation of wnt/β-catenin signaling in embryos lacking Prdm5. PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo.
Organism species: Homo sapiens (Human)
  • Protein RPS622Hu01Recombinant PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyPAS622Hu01Polyclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyMAS622Hu21Monoclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSES622HuELISA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSCS622HuCLIA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPS622Mu01Recombinant PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyPAS622Mu01Polyclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyMAS622Mu21Monoclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSES622MuELISA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSCS622MuCLIA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPS622Ra01Recombinant PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyPAS622Ra01Polyclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • AntibodyMAS622Ra21Monoclonal Antibody to PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSES622RaELISA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
  • Assay KitSCS622RaCLIA Kit for PR Domain Containing Protein 5 (PRDM5)Customize
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