Pancreatic Lipase Related Protein 1 (PNLIPRP1)

PNLIPRP1 has 68% amino acid sequence identity with PNLIP, 63% identity with PNLIPRP2, and 18 to 34% identity with gastric lipase), lipoprotein lipase, and hepatic lipase . Western blot analysis of recombinant PNLIPRP1 expressed in mammalian cells detected a secreted 47-kD protein. Recombinant PNLIPRP1 did not have lipolytic activity in a standard pancreatic lipase assay, suggesting that PNLIPRP1 may have different substrate and/or cofactor requirements than those present in the assay. Northern blot analysis of pancreas RNA detected a major 1.8-kb PNLIPRP1 transcript.

The expression level of PNLIPRP1 in pancreas was approximately 4-fold lower and 6-fold higher than the expression levels of PNLIP and PNLIPRP2, respectively.