Paraneoplastic Antigen MA2 (PNMA2)
Ma2/Ta; Ma2Ta; RGAG2; Autoantigen Ta; 40 kDa neuronal protein; Onconeuronal antigen Ma2; Paraneoplastic neuronal antigen MM2
In patients with cancer, symptoms of limbic and brainstem dysfunction may result from a paraneoplastic disorder. Paraneoplastic limbic or brainstem encephalitis occurs more frequently with testicular cancer than with most other cancers.
By immunohistochemical and immunoblotting techniques, Voltz et al. (1999) detected antibodies in serum and cerebrospinal fluid against a 40-kD neuronal protein in 10 of 13 patients with testicular cancer and paraneoplastic limbic or brainstem encephalitis, or both. They designated the protein MA2, and found that it was selectively expressed by normal brain tissue and by the testicular tumors of the patients. MA2 shares homology with MA1, a 'brain-testis-cancer' gene related to other neoplastic syndromes and tumors.
Organism species: Homo sapiens (Human)
- Recombinant protein RPH343Hu01 Recombinant Paraneoplastic Antigen MA2 (PNMA2) In Stock
- Polyclonal antibody PAH343Hu01 Polyclonal Antibody to Paraneoplastic Antigen MA2 (PNMA2) In Stock
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPH343Ra01 Recombinant Paraneoplastic Antigen MA2 (PNMA2) In Stock
- Polyclonal antibody PAH343Ra01 Polyclonal Antibody to Paraneoplastic Antigen MA2 (PNMA2) In Stock
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