Patatin Like Phospholipase Domain Containing Protein 5 (PNPLA5)

PNPLA5, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli.By database analysis, followed by screening of human EST databases, Wilson et al. (2006) identified PNPLA5, which encodes a 429-amino acid protein containing a patatin-like domain and 2 glycosaminoglycan sites. Structural analysis determined that the patatin-like domain was composed of a beta-sheet sandwiched by alpha-helices in approximately 3 layers. Quantitative RT-PCR analysis showed that PNPLA5 was expressed at moderate levels in brain and at very low levels in liver.Gao and Simon (2007) measured retinol transacylation activity and found that PNPLA5 appeared to inhibit transacylation catalyzed by endogenous enzymes, but it had measurable retinylester hydrolysis activity.