Peroxisome Proliferator Activated Receptor Beta (PPARb)

Peroxisome Proliferator Activated Receptor Beta (PPARb)
is only weakly activated by fatty acids, prostaglandins and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer
A role for the nuclear receptor peroxisome proliferator-activated receptor-b (PPARb) in oncogenesis has been suggested by a number of observations but its precise role remains elusive. Prostaglandin I2 (PGI2,prostacyclin), a major arachidonic acid (AA) derived cyclooxygenase (Cox) product, has been proposed as a PPARb agonist. Surprisingly, however, 4-OHT failed to activate PPARb transcriptional activity,indicating that PGI2 is insufficient for PPARb activation. Conversely, inhibition of PGIS blocked PGI2 synthesis but did not affect the AA mediated activation of PPARb.

Organism species: Danio rerio (Zebrafish)