Peroxisome Proliferator Activated Receptor Beta (PPARb)
is only weakly activated by fatty acids, prostaglandins and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer
A role for the nuclear receptor peroxisome proliferator-activated receptor-b (PPARb) in oncogenesis has been suggested by a number of observations but its precise role remains elusive. Prostaglandin I2 (PGI2,prostacyclin), a major arachidonic acid (AA) derived cyclooxygenase (Cox) product, has been proposed as a PPARb agonist. Surprisingly, however, 4-OHT failed to activate PPARb transcriptional activity,indicating that PGI2 is insufficient for PPARb activation. Conversely, inhibition of PGIS blocked PGI2 synthesis but did not affect the AA mediated activation of PPARb.
Organism species: Danio rerio (Zebrafish)
- Customized Service n/a Recombinant Peroxisome Proliferator Activated Receptor Beta (PPARb) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Beta (PPARb) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Beta (PPARb) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Peroxisome Proliferator Activated Receptor Beta (PPARb) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Peroxisome Proliferator Activated Receptor Beta (PPARb) ELISA Kit Customized Service Offer