Phosphatase And Actin Regulator 2 (PHACTR2)

PHACTR2 had an apparent molecular mass of 95 kD by SDS-PAGE. RT-PCR detected PHACTR2 in all tissues examined. Expression was highest in heart, ovary, and testis, intermediate in lung, liver, skeletal muscle, and kidney, and low in brain, pancreas, and spleen.

By searching databases for sequences similar to rat Phactr1, Allen et al. (2004) identified a family of 4 PHACTR genes in mouse and human, including PHACTR2. The PHACTR proteins share highest similarity in sequences surrounding the N- and C-terminal RPEL repeats and in the C-terminal actin- and protein phosphatase-1 (PP1)-binding domains. In situ hybridization of rat brain showed Phactr2 highly expressed in cerebellum, choroid plexus, and thalamus.