Phosphodiesterase 6C, cGMP Specific (PDE6C)

In the retinal rods, phosphodiesterase (PDE) is composed of an 88-kD alpha subunit, an 84-kD beta subunit and two 11-kD gamma subunits, while in cones PDE occurs as a homodimer of two 94-kD alpha-prime subunits (PDE6C) that are associated with 3 smaller proteins of 11, 13, and 15 kD. The 11- and 13-kD proteins are similar to the rod gamma subunits, while the 15-kD delta subunit binds to both cone and rod PDE.

It was found to be 3,455 bp in length and to encode a polypeptide of 858 amino acids and a calculated molecular mass of 99,169 Da. The deduced amino acid sequence displayed high homology to the alpha, beta, and alpha-prime subunits of bovine, human, chicken, and mouse photoreceptor PDEs.