Phosphoinositide Dependent Protein Kinase 1 (PDPK1)

PDK1; PkB-Like 1
Phosphoinositide Dependent Protein Kinase 1 (PDPK1)
PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signalling. Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals nescessary for normal mammalian development.
Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resitant to cancer brought about by hyperactivation of the PI3K pathway (PTEN +/-).The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPC246Ra01Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Customize
  • AntibodyPAC246Ra01Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Customize
  • AntibodyMAC246Ra21Monoclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Customize
  • Assay KitSEC246RaELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Customize
  • Assay KitSCC246RaCLIA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Customize
Leave your messages here

Welcome to our website. If you have any questions, please send a message to us.
We'll Feedback to you within 24 hours.Our work time is from AM 8:00 to PM 4:30 (U.S. Central Time)

  • Sales:sales@cloud-clone.us
  • After-sales:service@cloud-clone.us
  • Email:mail@cloud-clone.us
  • Close