Phospholamban (PLN)
PLB; CMD1P; Cardiac phospholamban
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation.
Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB884Hu01 Recombinant Phospholamban (PLN) In Stock
- Polyclonal antibody PAB884Hu01 Polyclonal Antibody to Phospholamban (PLN) In Stock
- Customized Service n/a CLIA Kit for Phospholamban (PLN) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Phospholamban (PLN) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPB884Mu01 Recombinant Phospholamban (PLN) In Stock
- Recombinant protein RPB884Mu02 Recombinant Phospholamban (PLN) In Stock
- Polyclonal antibody PAB884Mu01 Polyclonal Antibody to Phospholamban (PLN) In Stock
- Polyclonal antibody PAB884Mu02 Polyclonal Antibody to Phospholamban (PLN) In Stock
- Sandwich ELISA SEB884Mu ELISA Kit for Phospholamban (PLN) In Stock
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Phospholamban (PLN) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Phospholamban (PLN) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Phospholamban (PLN) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Phospholamban (PLN) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Phospholamban (PLN) ELISA Kit Customized Service Offer