Phospholamban (PLN)

PLB; CMD1P; Cardiac phospholamban
Phospholamban (PLN)
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation.
Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPB884Ra01Recombinant Phospholamban (PLN)Customize
  • AntibodyPAB884Ra01Polyclonal Antibody to Phospholamban (PLN)Customize
  • AntibodyMAB884Ra21Monoclonal Antibody to Phospholamban (PLN)Customize
  • Assay KitSEB884RaELISA Kit for Phospholamban (PLN)Customize
  • Assay KitSCB884RaCLIA Kit for Phospholamban (PLN)Customize
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