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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Phospholamban (PLN)
PLB; CMD1P
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation.
Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPB884Hu01 Recombinant Phospholamban (PLN) Customize
Antibodies PAB884Hu01 Polyclonal Antibody to Phospholamban (PLN) Customize
MAB884Hu21 Monoclonal Antibody to Phospholamban (PLN) Customize
Assay Kits SEB884Hu ELISA Kit for Phospholamban (PLN) Customize
SCB884Hu CLIA Kit for Phospholamban (PLN) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPB884Mu01 Recombinant Phospholamban (PLN) Customize
RPB884Mu02 Recombinant Phospholamban (PLN) Customize
Antibodies PAB884Mu01 Polyclonal Antibody to Phospholamban (PLN) Customize
PAB884Mu02 Polyclonal Antibody to Phospholamban (PLN) Customize
MAB884Mu21 Monoclonal Antibody to Phospholamban (PLN) Customize
Assay Kits SEB884Mu ELISA Kit for Phospholamban (PLN) In Stock
SCB884Mu CLIA Kit for Phospholamban (PLN) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPB884Ra01 Recombinant Phospholamban (PLN) Customize
Antibodies PAB884Ra01 Polyclonal Antibody to Phospholamban (PLN) Customize
MAB884Ra21 Monoclonal Antibody to Phospholamban (PLN) Customize
Assay Kits SEB884Ra ELISA Kit for Phospholamban (PLN) Customize
SCB884Ra CLIA Kit for Phospholamban (PLN) Customize