Phospholipase A2, Group IVC (PLA2G4C)

PLA2G4C encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. PLA2G4C has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene.The cPLA2-gamma sequence predicts a 541-amino acid polypeptide with 28% identity to cPLA2-alpha. Expression studies showed that cPLA2-gamma liberates arachidonate from phospholipid, cleaving at either sn-1 or sn-2 sites. cPLA2-gamma is prenylated, membrane-associated, and calcium-independent.