Phosphotriesterase Related Protein (PTER)

The deduced 349-amino acid protein has a calculated molecular mass of 39.2 kD. Northern blot analysis detected highest Pter expression in kidney and lower expression in liver. Pter was not detected in fetal kidney, but it was expressed during the postnatal period and showed highest levels in adult kidney. In situ hybridization revealed highest Pter mRNA expression in proximal tubules.

Pter was significantly underexpressed in cystic kidneys of the cpk mouse, a model of human autosomal recessive polycystic kidney disease (ARPKD). Pter expression was significantly decreased upon acute renal injury induced by a single intraperitoneal injection of folic acid, and normal Pter levels returned upon recovery of kidney function.