Placenta Cross Immune Reaction Antigen 1 (PCIA1)
DDA1; C19orf58; DET1 And DDB1 Associated 1
DET1 (de-etiolated 1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis thaliana CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian DET1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 associated 1), and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes. DDD-E2 complexes interact with multiple ubiquitin E3 ligases. The E2 component cannot maintain the ubiquitin thioester linkage once bound to the DDD core, rendering mammalian DDD-E2 equivalent to the Arabidopsis CDD complex. While free UBE2E-3 is active and able to enhance UbcH5/Cul4A activity, the DDD core specifically inhibits Cul4A-dependent polyubiquitin chain assembly in vitro. Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Placenta Cross Immune Reaction Antigen 1 (PCIA1) Recombinant Protein Customized Service Offer
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- Customized Service n/a Polyclonal Antibody to Placenta Cross Immune Reaction Antigen 1 (PCIA1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Placenta Cross Immune Reaction Antigen 1 (PCIA1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Placenta Cross Immune Reaction Antigen 1 (PCIA1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Placenta Cross Immune Reaction Antigen 1 (PCIA1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Placenta Cross Immune Reaction Antigen 1 (PCIA1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Placenta Cross Immune Reaction Antigen 1 (PCIA1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Placenta Cross Immune Reaction Antigen 1 (PCIA1) ELISA Kit Customized Service Offer