Pleckstrin 2 (PLEK2)

Using the sequence of human pleckstrin (PLEK) as query, Hu et al. (1999) identified mouse pleckstrin-2, which encodes a deduced 353-amino acid protein. By EST database searching with mouse Plek2, they identified the human homolog, which encodes a deduced protein that is identical to mouse Plek and 39% identical to human PLEK.

Like PLEK, human PLEK2 contains an N- and a C-terminal PH domain plus an intervening DEP domain. Unlike PLEK, which contains 3 phosphorylation sites, PLEK2 contains only 1 site comparable to ser117 in PLEK. Northern blot analysis of human tissues detected ubiquitous expression of a 1.7-kb PLEK2 transcript, with highest expression in thymus, prostate, testis, ovary, small bowel, and large bowel.