Pleckstrin Homology Domain Containing Family F, Member 2 (PLEKHF2)

Pleckstrin homology domain-containing family F member 2 is a protein encoded by the PLEKHF2 gene. Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

This domain can bind Phosphatidylinositol lipids within biological membranes, and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.