Pleckstrin Homology Domain Containing Family H, Member 2 (PLEKHH2)

The mouse and human PLEKKH2 proteins contain pleckstrin (PLEK) homology (PH), myth4, and band 4.1 domains. PH domains are implicated in phosphatidylinositol phospholipid signaling, and band 4.1 domains interact with integral membrane proteins. The combination of myth4 and band 4.1 domains is found in several unconventional myosin proteins that colocalize with actin-rich processes. Northern blot analysis and RT-PCR of various mouse tissues detected Plekhh2 expression in testis only. Northern and Western blot analyses of human and mouse kidney fractions detected PLEKHH2 mRNA and protein in the glomerulus fraction, but not in fractions lacking glomeruli. The PLEKHH2 protein had an apparent molecular mass of 120 kD.