Plexin A2 (PLXNA2)

PLXNA2encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

PLXNA2 is associated with schizophrenia. and anxiety.The proteins encoded by all 4 genes contained large cytoplasmic domains characterized by a distinctive highly conserved sequence that they called the SEX domain.