Poly ADP Ribose Polymerase 12 (PARP12)

By database searching with evolutionarily conserved sequences in the TIPARP gene, Katoh and Katoh (2003) identified 2 human genes, PARP12 and ZAP (ZC3HAV1), that encode deduced proteins with the same conserved regions: a WWE domain, a PARP-like domain, and a TPH domain. The N-terminal region of the TPH domain in all 3 genes contains a CCCH-type zinc finger. Katoh and Katoh (2003) noted that PARP12 and ZCH3HAV1 share 27.5% and 26% overall amino acid sequence identity with TIPARP, respectively. The PARP12 gene encodes a deduced 701-amino acid protein.The deduced proteins of 2 human genes, which they called FLJ226093 (PARP12) and ZAP (ZC3HAV1), contain the same 3 conserved domains and share 27.5% and 26% overall sequence identity with TIPARP, respectively.